منابع مشابه
Sirolimus-tacrolimus combination immunosuppression.
A series of 32 recipients of liver, kidney, or pancreas transplants who were treated with sirolimus and low-dose tacrolimus experienced a low rate of rejection and excellent graft function without drug-related toxic effects.
متن کاملAllopurinol in combination with thiopurine induces mucosal healing and improves clinical and metabolic outcomes in IBD
Background Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD). Excessive methylation via thiopurine methyltransferase (TPMT) frequently causes therapeutic failure. Allopurinol reduces excessive 6-methyl-mercaptopurine (6-MMP) while enhancing 6-thioguanine (6-TGN) levels. The aim of this study was to evaluate clinic...
متن کاملCombination of thiopurines and allopurinol: adverse events and clinical benefit in IBD.
BACKGROUND AND AIMS Allopurinol has been presented as a safe and effective adjunct to thiopurine therapy in inflammatory bowel disease (IBD). We aimed to determine the rate of infectious complications and clinical successes with a combination of thiopurine/allopurinol in IBD, and to identify which variables predict 6-thioguanine, 6-methylmercaptopurine, and white blood cell levels. Additionally...
متن کاملTopical therapies in IBD
Due to misunderstandings about their effectiveness and feasibility, topical (or rectal) therapies with aminosalicylates (5-aminosalicylic acid, 5-ASA) and steroids are often underused in patients with ulcerative colitis (UC). However, many of these patients could be treated solely with rectal/topical therapies, or could benefit from them in combination with oral therapies. We review the evidenc...
متن کاملAdvAnces in iBd
SN The incidence and prevalence of inflammatory bowel disease (IBD) are lower in Asia than in the West. However, time trend studies from Asia (Japan, Korea, and Hong Kong) have shown that the incidence of IBD has increased over the past 2 decades. Differences have also been observed in the incidence of IBD across different geographic regions within Asia. In Asia, ulcerative colitis (UC) is more...
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ژورنال
عنوان ژورنال: Inflammatory Bowel Diseases
سال: 2018
ISSN: 1078-0998,1536-4844
DOI: 10.1093/ibd/izx065